MACS® GMP grade Cell Culture and Stimulation
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The quality of starting materials dramatically influences the properties of the final cellular product. For the development of applications involving cellular therapies, strict procedures according to GMP guidelines are mandatory. All materials used, such as antibodies, antigens, cytokines, cell culture bags, and cell culture media, must comply with GMP specifications.
| MACS® GMP Media |
MACS® GMP Media have been developed for the demands of specific cell types, such as T cells, regulatory T cells, HSCs, PSCs, or MSCs. These high performance media enable excellent growth or differentiation, high cell viability, and consistency under serum-free conditions. Filling in flexible bags allows seamless GMP-compliant manufacturing of cellular products. Consistently high product standards are ensured by functional testing of every batch during quality control and extensive documentation including product quality certificates, product data sheets, and regulatory support files.
| Popular products |
TexMACS medium
| Cell Type |
Order no. |
Product |
Size |
|
T cell or CIK |
170-076-306 |
2000 mL |
|
|
170-076-307 |
1000 mL |
||
|
170-076-309 |
1000 mL |
StemMACS MSC XF and MSC Brew medium
|
Cell Type |
Order no. |
Product |
Size |
|
mesenchymal stem cells (MSCs) |
170-076-326 |
500 mL |
|
|
170-076-325 |
2000 mL |
NK MACS medium
|
Cell Type |
Order no. |
Product |
Size |
|
NK cell |
170-076-356 |
2000 mL |
|
Cell Type |
Order no. |
Product |
Size |
|
dendritic cell (DC) |
170-076-302 |
DendriMACS GMP Medium |
450 mL |
|
Hematopoietic stem cells (HSCs) |
170-076-310 |
HSC - Brew GMP Medium |
500ml |
|
iPS cell |
170–076–317 |
iPS–Brew GMP Basal Medium |
500mL |
|
170–076–318 |
iPS–Brew GMP Supplement R |
10mL |
|
|
Antiboitcs |
170-076-308 |
200 nmol |
| MACS GMP Cytokines |
The MACS® GMP Cytokine Portfolio offers a large variety of highly active and pure cytokines. They perfectly meet the requirements for high-quality raw materials for cell manufacturing of cell-based therapies. Consistently high product quality and safety of all MACS GMP Cytokines is ensured by aseptic filling, lyophilization without carrier protein or preservatives, rigorous quality control, and an outstanding regulatory support.
MACS GMP Cytokines are manufactured and tested under an ISO 13485 quality management system, in compliance with relevant GMP guidelines, as well as the requirements laid down in the Ph. Eur. Chapter 5.2.12 and USP <1043> on ancillary materials.
1043
GMP cytokines products:
|
Order no. |
Product |
Size |
| 170-076-406 | MACS GMP Recombinant Human EGF | 100 μg |
| 170-076-407 | MACS GMP Recombinant Human EGF | 500 μg |
| 170-076-107 | MACS GMP Recombinant Human FGF-2 | 25 μg |
| 170-076-125 | MACS GMP Recombinant Human FGF-2 | 500 μg |
| 170-076-132 | MACS GMP Recombinant Human Flt3-Ligand | 100 μg |
| 170-076-112 | MACS GMP Recombinant Human GM-CSF | 25 μg |
| 170-076-136 | MACS GMP Recombinant Human GM-CSF | 250 μg |
| 170-076-102 | MACS GMP Recombinant Human IL-1β | 25 μg |
| 170-076-148 | MACS GMP Recombinant Human IL-2 | 25 μg |
| 170-076-146 | MACS GMP Recombinant Human IL-2 | 100 μg |
| 170-076-147 | MACS GMP Recombinant Human IL-2 | 500 μg |
| 170-076-110 | MACS GMP Recombinant Human IL-3 | 25 μg |
| 170-076-101 | MACS GMP Recombinant Human IL-4 | 25 μg |
| 170-076-135 | MACS GMP Recombinant Human IL-4 | 250 μg |
| 170-076-104 | MACS GMP Recombinant Human IL-6 | 10 μg |
| 170-076-111 | MACS GMP Recombinant Human IL-7 | 25 μg |
| 170-076-114 | MACS GMP Recombinant Human IL-15 | 25 μg |
| 170-076-115 | MACS GMP Recombinant Human IL-21 | 25 μg |
| 170-076-149 | MACS GMP Recombinant Human SCF | 10 μg |
| 170-076-133 | MACS GMP Recombinant Human SCF | 100 μg |
| 170-076-103 | MACS GMP Recombinant Human TNF-α | 25 μg |
| 170-076-134 | MACS GMP Recombinant Human TPO | 50 μg |
| 170-076-166 | MACS GMP Recombinant Human TGF-β1 | 5 μg |
| 170-076-167 | MACS GMP Recombinant Human TGF-β1 | 25 μg |
| 170-076-168 | MACS GMP Recombinant Human TGF-β1 | 100 μg |
| Cell stimulation kits |
- MACS GMP T Cell TransAct: The reagent is optimized to activate and expand 1×108 enriched T cells.
- MACS GMP T Cell TransAct - Large Scale: The reagent is optimized to activate and expand up to 4×108 enriched T cells.
Setting the stage for automated production of engineered T cells
| PepTivator Peptide Pool |
PepTivator Peptide Pools antigens:
Effective stimulation:
When you are developing your research towards clinical applications, choose from this portfolio of GMP-grade peptide pools.
- Designed for the stimulation of CD4+ and CD8+ T cells
- Optimized for the use with the CliniMACS® System
- Constantly growing product portfolio
PepTivator Peptide Pools GMP Products:
| 貨號 | 品項 | 包裝 | |
| 170–076–131 | MACS GMP Aspergillus fumigatus Lysate | for stimulation of 1×10^9 cells | 4 mg |
| 170–076–106 | MACS GMP PepTivator AdV5 Hexon | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| 170–076–139 | MACS GMP PepTivator BKV LT | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| 170–076–138 | MACS GMP PepTivator BKV VP1 | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| 170–076–130 | MACS GMP PepTivator EBV BZLF1 | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| 170–076–129 | MACS GMP PepTivator EBV EBNA–1 | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| 170–076–122 | MACS GMP PepTivator EBV LMP2A | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| 170–076–143 | MACS GMP PepTivator EBV Select | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| 170–076–109 | MACS GMP PepTivator HCMV pp65 | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| 170–076–158 | MACS GMP PepTivator HPV16–E6 | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| 170–076–159 | MACS GMP PepTivator HPV16–E7 | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| 170–076–153 | MACS GMP PepTivator MAGE–A3 | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| 170–076–151 | MACS GMP PepTivator Mucin–1 | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| 170–076–137 | MACS GMP PepTivator NY–ESO–1 | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| 170–076–157 | MACS GMP PepTivator PRAME 1 | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| 170–076–152 | MACS GMP PepTivator Survivin 1 | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| 170–076–123 | MACS GMP PepTivator WT1 | for stimulation of 1×10^9 cells | 60 nmol/peptide |
| MACS® GMP Vectofusin®-1 (Order no. 170-076-165） |
MACS GMP Vectofusin-1 is a non-toxic histidin-rich amphipathic peptide which exerts as viral transduction enhancer. Unlike other transduction enhancers, it is not dependent on immobilization of target cells and therefore compatible with automated processes.
Viral transduction of suspension cells using retroviral vectors is often inefficient and requires the use of transduction enhancers. MACS GMP Vectofusin-1 is a fully synthetic, non-toxic, cationic amphipathic peptide with viral transduction enhancing capacity, enabling higher transduction levels with low amounts of retroviral vector. MACS GMP Vectofusin-1 promotes the entry of several retroviral pseudo-types into target cells when added to the culture medium.
Applications:
- Enhancement of lentiviral transduction
- Enhancement of retroviral transduction
MACS Cell Therapy Manufacture 
