Antigens for SARS-CoV-2 research

Links：https://www.miltenyibiotec.com/SG-en/lp/recombinant-antigens ...

SARS-CoV-2 antigens offer researchers the possibility to investigate virus-specific immune responses, including antigen-specific B cells and antibodies.

All our antigens for SARS-CoV-2 research are available in different filling sizes and with or without biotinylation. Recombinantly expressed antigens are tagged with His and AviTag™.

Applications of SARS-CoV-2 antigens:

Detection of patient-derived antibodies
Characterization of patient-specific immune responses
Detection and phenotyping of virus-specific B cells
Enrichment of virus-specific B cells
Analysis of virus binding to host cells
Protein detection assays

Schematic overview of our antigens for SARS-CoV-2 research:

This overview illustrates major structural SARS-CoV-2 proteins: The spike protein (S), the nucleoprotein (N), the envelope protein (E), and the membrane protein (M). The spike protein consists of three spike monomers, which form a homotrimeric structure (spike trimer) on the SARS-CoV-2 surface. Each spike monomer consists of an S1 and an S2 subunit, connected at the furin cleavage site. During viral fusion, the receptor binding domain (RBD) binds the host cell target receptor ACE2, whereas the S2 domain mediates membrane fusion.
We offer various antigens based on the structural SARS-CoV-2 proteins as well as the target receptor ACE2.

Overview of our antigens for SARS-CoV-2 research:

Order no.	Sequence Part	Source	Tag	Biotinylated	Size (μg)
Antigens for SARS-CoV-2 research
Recombinant Human ACE2
130-127-516	Q18 to S740	HEK	His, AviTag™	No	100
130-127-456				No	25
130-127-465				YES	50
130-127-442				YES	10
130-127-466	Q18 to D615	Insect cells		No	100
130-127-444				No	25
130-127-464				YES	50
130-127-468				YES	10
spike
Recombinant SARS-CoV-2 Spike-Trimer (HEK)
130-127-683		HEK	His, AviTag™	NO	50
130-127-684	V16 to K1211 (K986P, V987P, RRAR682–685GSAG), with T4 fibritin trimerization motif			NO	10
130-127-685				YES	25
Recombinant SARS-CoV-2 Spike-Prot (HEK)
130-127-680	V16 to K1211	HEK	His, AviTag™	NO	50
130-127-681	(K986P, V987P, RRAR682–685GSAG)			NO	10
130-127-682				YES	25
Furin cleavage site (and control)
SARS-CoV-2 Furin Cleavage Site and SARS-CoV-2 Furin Cleavage Site Control
130-127-689	S673 to S691 (RRAR)			Yes	100
130-127-690				Yes (FAM-biotin)	100
130-127-691	S673 to S691 (RRAR682–685GSAG)			YES	100
130-127-692				Yes (FAM-biotin)	100
Receptor binding domain
Recombinant SARS-CoV-2 RBD
130-127-518	R319 to S591	HEK	His, AviTag™	No	100
130-127-448				No	25
130-127-457				YES	50
130-127-458				YES	10
130-127-453		Insect cells		No	100
130-127-463				No	25
130-127-469				YES	50
130-127-445				YES	10
S domain
Recombinant SARS-CoV-2 Spike-S1 (HEK)
130-127-854	V16 to P681	HEK	His, AviTag™	NO	50
130-127-852				NO	10
130-127-853				YES	25
Recombinant SARS-CoV-2 Spike-S2 (insect cells)
130-127-686	S686 to K1211 (K986P, V987P)	Insect cells	His, AviTag™	NO	50
130-127-687				NO	10
130-127-688				YES	25
nucleoprotein
Recombinant SARS-CoV-2 Nucleoprotein
130-127-517	Full length
130-127-462	S2 to A419	HEK	His, AviTag™	NO	50
130-127-467				NO	10
130-127-454				YES	25
envelope protein
SARS-CoV-2 envelope antigens
130-127-446	(Region:C-terminus) L34 to V75			NO	100
130-127-451				YES	100
130-127-455	(Region:N-terminus) M1 to S16			NO	100
130-127-461				YES	100
130-127-450	(Region:Helical segment 2 (H2)) S55 to V75			NO	100
130-127-452				YES	100

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